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Diagnostic
protocol from the Annals of Internal Medicine
Holmes et al published gudelines in 1988 in the Annals of Internal
Medicine. The matter was reviewed in 1994 (Fukuda et al Ann Int Med
1994; see appendix II in CFS Handbook) when an international panel
suggested the following diagnostic guidelines:
A thorough medical history, physical examination, mental status,
and laboratory tests must be conducted to identify underlying conditions
that require treatment. Diagnosis cannot be made without such an
evaluation. A patient must satisfy these criteria, to receive a diagnosis
of CFS.
1. Clinically evaluated, unexplained persistent or relapsing
chronic fatigue of 6 months or longer duration that is of new or definite
onset, not lifelong, with other known medical conditions excluded by
clinical diagnosis. It is not the result of ongoing exertion, not substantially
alleviated by rest, and results in substantial reduction in previous
levels of occupational, educational and social activities.
2. The concurrent occurrence of four or more of these symptoms:
substantial impairment in short-term memory or concentration;
sore throat;
tender lymph nodes;
muscle pain;
multi-joint pain without swelling or redness;
headaches of a new type, pattern, or severity;
unrefreshing sleep;
post-exertional malaise lasting more than 24 hours.
These symptoms must have persisted or recurred during six or
more consecutive months of illness and must not have predated the
fatigue
A comprehensive medical history and careful
physical examination is required to make the diagnosis
the following tests are required within the last 3 months
Comprehensive blood tests (SMAC )/ CBC
...T cells including CD57
Thyroid panel, T3,T4 and TSH
...Thyroid peroxidase
SERUM TESTS for :
...Viral titers of HHV6 EBV, CMV
...serum amino acids... including carnitine,glutathione, cystine,argenine,methionine
...Lymes Disease --- Western Blot, Eliza and PCR
...Mycoplasma pneum.,
...Clamydia pneum.,
...Candida
...Babesia ,
...Erlichia
EKG ,
cardiac output Impedance Cardiography( this is an upgraded tilt table. Dr Enlander is one of the few physicians with this new Cardiac Output equipment),
Spirometry
Cancer screening tests Ca125 (female Ovarian) ; PSA/ PAP (male prostate)
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